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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LRP1 All Species: 18.18
Human Site: S4517 Identified Species: 44.44
UniProt: Q07954 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q07954 NP_002323.2 4544 504575 S4517 L Y M G G H G S R H S L A S T
Chimpanzee Pan troglodytes XP_515817 4636 518955 C4609 L Y M D G Q N C R N S L G S V
Rhesus Macaque Macaca mulatta XP_001117994 4592 514768 C4565 L Y M D G Q N C R N S L G S V
Dog Lupus familis XP_538245 4526 502835 S4499 L Y M G G H G S R H S L A S T
Cat Felis silvestris
Mouse Mus musculus Q91ZX7 4545 504723 S4518 L Y M G G H G S R H S L A S T
Rat Rattus norvegicus P98158 4660 519258 T4646 G Y T A T E D T F K D T A N L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P98157 4543 507114 S4516 L Y M G A H S S R N S L A S T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001920591 4547 508513 S4521 L Y M G A H N S R N S L A S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q04833 4753 526406 L4737 K K E K A D P L R V D N P L Y
Sea Urchin Strong. purpuratus XP_787118 4478 501013 Q4446 V Y N S Y L N Q R G S E L S L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59.7 60 96.5 N.A. 98 37.2 N.A. N.A. 86.7 N.A. 76.2 N.A. N.A. N.A. 31.6 44.7
Protein Similarity: 100 74.1 74.6 97.5 N.A. 98.9 53 N.A. N.A. 93 N.A. 86.2 N.A. N.A. N.A. 48.3 61.3
P-Site Identity: 100 53.3 53.3 100 N.A. 100 13.3 N.A. N.A. 80 N.A. 80 N.A. N.A. N.A. 6.6 26.6
P-Site Similarity: 100 60 60 100 N.A. 100 26.6 N.A. N.A. 86.6 N.A. 86.6 N.A. N.A. N.A. 6.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 30 0 0 0 0 0 0 0 60 0 0 % A
% Cys: 0 0 0 0 0 0 0 20 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 20 0 10 10 0 0 0 20 0 0 0 0 % D
% Glu: 0 0 10 0 0 10 0 0 0 0 0 10 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % F
% Gly: 10 0 0 50 50 0 30 0 0 10 0 0 20 0 0 % G
% His: 0 0 0 0 0 50 0 0 0 30 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 10 0 10 0 0 0 0 0 10 0 0 0 0 0 % K
% Leu: 70 0 0 0 0 10 0 10 0 0 0 70 10 10 20 % L
% Met: 0 0 70 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 40 0 0 40 0 10 0 10 0 % N
% Pro: 0 0 0 0 0 0 10 0 0 0 0 0 10 0 0 % P
% Gln: 0 0 0 0 0 20 0 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 90 0 0 0 0 0 0 % R
% Ser: 0 0 0 10 0 0 10 50 0 0 80 0 0 80 0 % S
% Thr: 0 0 10 0 10 0 0 10 0 0 0 10 0 0 50 % T
% Val: 10 0 0 0 0 0 0 0 0 10 0 0 0 0 20 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 90 0 0 10 0 0 0 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _